In an effort to find out whether certain protein was the trigger for rheumatoid arthritis, scientists with Toledo University accidentally found a vaccine against painful autoimmune disease. Protein-based vaccines are found to produce a rapid, strong and durable immune system response that offers protection from disease.

Rheumatoid arthritis, like most autoimmune diseases, triggered through mechanisms that are not quite understood, so it is difficult to develop a way to prevent its condition. No drug is known for the current disease, but the new experimental vaccine developed can pave the way for prevention maintenance.

Hansel Ritu Chakravarti University has studied 14-3-3 zeta, protein, for that role can be played in immune diseases. Past research caused this protein exploration as a trigger behind rheumatoid arthritis, but it was no matter. Instead, use gene editing to remove proteins on animal models that result in developing severe arthritis at a younger age than distinctive age.

Equipped with new knowledge, scientists behind this effort develop a vaccine based on the purified version of this protein. Vaccines trigger a durable immune response with animal models that offer protection against rheumatoid arthritis. Not only that, but this vaccine also causes the existing arthritis in animals to “completely disappear.”

Scientists found that their experimental vaccines also improved bone quality, indicating that this vaccine – or preferred – may also have used outside rheumatoid arthritis. The team is now looking for a pharmaceutical company to partner with toxicity and safety studies, note that they hope to finally start a pracinate trial for vaccines.